VACCINO CONTRO LE BRUCELLOSI UMANE E PROCEDIMENTO PER LA SUA PREPARAZIONE

Vaccine against brucellosis comprises, in a suitable vehicle, the phenol-insoluble fraction (A) of Brucella abortus, esp. the strain B19. Pref. (A) is 1.7-2.3, esp. 2, mg (dry basis) per ml solvent and the vaccine is esp. formulated in unit doses of 0.5 ml. The pref. vehicle is a phenol-contg. physi...

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Hauptverfasser:	DESMETTRE PHILIPPE, ASSELINEAU JEAN, LACAVE CHARLOTTE, WADOUX PATRICK, SERRE ARLETTE, ROUX JACQUES
Format:	Patent
Sprache:	ita
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Vaccine against brucellosis comprises, in a suitable vehicle, the phenol-insoluble fraction (A) of Brucella abortus, esp. the strain B19. Pref. (A) is 1.7-2.3, esp. 2, mg (dry basis) per ml solvent and the vaccine is esp. formulated in unit doses of 0.5 ml. The pref. vehicle is a phenol-contg. physiological solvent. The vaccine is made from intact B.abortus cells by (1) removal of lipids; (2) drying; (3) extracting with phenol (esp. phenol satd. with water), at about 60 deg.C; (4) washing the filtered and purified prod. and (5) forming into a homogeneous, sterile suspension. The vaccine is suitable for admin. to humans, e.g. farm workers or veterinary surgeons, and is effective against B. melitensis and B. suis as well as B. abortus. It is nontoxic and induces only very mild hypersensitivity reactions.