DERIVATI STEROIDEI DELLA SPIRO-OSSATIAZOLIDINA E PROCEDIMENTO PER LA LORO PREPARAZIONE

New steroid-spiro-oxathiazolidine derivatives pharmaceutical compositions containing the same, and to a process for the preparation thereof are disclosed. The new compounds have antimineral corticoide effects and have the following formula (I), (I) wherein R1 is a C1-3 alkyl or a C2-4 alkenyl group,...

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Hauptverfasser: SOLYOM SANDOR, SZONDI ELEONORA, TOLDY LAJOS, SCHAFER INGE, SZILAGYI KATALIN, HERMANN ILONA, BORVENDEG JANOS
Format: Patent
Sprache:ita
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Zusammenfassung:New steroid-spiro-oxathiazolidine derivatives pharmaceutical compositions containing the same, and to a process for the preparation thereof are disclosed. The new compounds have antimineral corticoide effects and have the following formula (I), (I) wherein R1 is a C1-3 alkyl or a C2-4 alkenyl group, and Z is a group of the formulae (II) to (VI), (II) (III) (IV) (V) (VI) wherein R2 is methyl or ethyl, R3 is hydrogen or methyl R4 is hydrogen, a C1-3 alkyl group, a di-(C1-4 alkyl)-amino-C1-4 alkyl group, a C2-4 alkylcarbonyl group, a C2-4 alkoxycarbonyl group or a C3-6 carboxyalkylcarbonyl group, and the dotted lines may represent additional valence bonds, with the proviso that if Z is a group of the formula (VI), a double bond exists between the carbon atoms in positions 4 and 5 or 5 and 6, and if R4 is a di-(C1-4 alkyl)-amino-C1-4 alkyl group or a C3-6 carboxyalkylcarbonyl group, the compounds may also be formed as their salts.