Ný aðferð við framleiðslu 4-metýl-5-(2-klóróetýl)-þíasól og hliðstæðum þess og ný milliefni við framleiðslu efnasambandanna

The invention relates to 5-(2-chloro-C2-5-alkyl)-4-methyl-1,3-thiazoles of the general formula I, wherein R is a straight-chain 2-chloro-C2-5-alkyl group and a process for their preparation, which is characterized by (A1) reacting a 3-(2-chloro-C2-5-alkyl)-3-thiocyanato-2-propanone of the general fo...

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Hauptverfasser: ERZSEBET MOLN BETAR NEE BAKO, MIH BETALY SUETOE, ILDIKO BUTTKAI, GYOERGY MIHALOVICS, L BETASZLO LEDNICZKY, IRP BETAD KOEV BETARI, ERZSEBET SZALAY, P BETAL KISS, ERZSEBET SZABO NEE KARDOS, PETER GYORI, GERGELY HEJA, FERENC SPERBER, S BETANDOR GARACZY, ENDRE P BETALOSI, ATTILA NEMETH, FERENC MOR BETASZ, K BETAROLY B BETAN, DEZSOE KORBONITS, IDA SZVOBODA NEE KANZEL, CSABA HUSZ BETAR, ISTV BETAN BONE, K BETAROLY GYUERE, CSABA GOENCZI
Format: Patent
Sprache:ice
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Zusammenfassung:The invention relates to 5-(2-chloro-C2-5-alkyl)-4-methyl-1,3-thiazoles of the general formula I, wherein R is a straight-chain 2-chloro-C2-5-alkyl group and a process for their preparation, which is characterized by (A1) reacting a 3-(2-chloro-C2-5-alkyl)-3-thiocyanato-2-propanone of the general formula IV in an organic solvent with gaseous hydrogen chloride to obtain the corresponding 2-chloro-5-(2-chloro-C2-5-alkyl)-4-methyl-1,3-thiazole of the general formula II or (A2) reacting a 3-(2-chloro-C2-5-alkyl)-3-thiocyanato-2-propanone of the above formula IV with an aqueous mineral acid to obtain the corresponding 5-(2-chloro-C2-5-alkyl)-2-hydroxy-4-methyl-1,3-thiazole of the general formula III and reacting the thus obtained compound of the formula III with a halogenating agent to obtain the corresponding 2-chloro-5-(2-chloro-C2-5-alkyl)-4-methyl-1,3-thiazole of the above formula II, and (B) hydrogenating the compound of the general formula II to obtain the 5-(2-chloro-C2-5-alkyl)-4-methyl-1,3-thiazole of the above general formula I. The invention further relates to intermediates for the above process, and pharmaceutical compositions comprising the compounds of formula I.