MODIFIED OLIGONUCLEOTIDES COMPRISING THIOL FUNCTIONS AND THE USE OF SAME FOR THE DETECTION OF NUCLEIC ACIDS

The present invention concerns a modified oligonucleotide having two or a plurality of thiol functions capable of being immobilised on a gold surface or on a grafted surface in particular a surface comprising at least one carbon carbon double bond or one carbon carbon triple bond or halogen acetamid...

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Bibliographische Detailangaben
Hauptverfasser:	LEREAU MYRIAM, MEYER ALBERT, MAYEN JULIE, MORVAN FRANÇOIS, FARRE CAROLE, VASSEUR JEAN JACQUES, FOURNIER WIRTH CHANTAL, CANTALOUBE JEAN FRANÇOIS, CHAIX CAROLE
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PHYSICS SUGARS TESTING
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Beschreibung
Zusammenfassung:	The present invention concerns a modified oligonucleotide having two or a plurality of thiol functions capable of being immobilised on a gold surface or on a grafted surface in particular a surface comprising at least one carbon carbon double bond or one carbon carbon triple bond or halogen acetamide functions preferably maleimide or acrylamide functions. The invention also concerns a method for detecting a nucleic acid in a biological sample comprising a step of detecting hybridisation between a modified oligonucleotide and an amplified target nucleic acid from the biological sample. The invention more specifically concerns a method for detecting genotyping or sequencing of a pathogenic organism preferably a virus.