"PREPARATION OF N-MONOFLUOROALKYL TROPANES"
The present invention relates to an improved synthesis of N-monofluoroalkyl tropanes using fluoroalkyl iodides or fluoroalkyl sulfonate esters. The invention also provides the use of such method to prepare the non-radioactive tropane intermediate FP-CIT, and its subsequent conversion to the '23...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | The present invention relates to an improved synthesis of N-monofluoroalkyl tropanes using fluoroalkyl iodides or fluoroalkyl sulfonate esters. The invention also provides the use of such method to prepare the non-radioactive tropane intermediate FP-CIT, and its subsequent conversion to the '23~-labelledra diopharmaceutical D ~ T S C A N ~ ~ (1231-ioflupane). Also provided is the use of fluoroalkyl iodides or fluoroalkyl 10 sulfonate esters in the alkylation method of the invention. |
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