"NOVEL CRYSTALLINE FORMS OF AN INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDEROGENASE TYPE 1."

"NOVEL CRYSTALLINE FORMS OF AN INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDEROGENASE TYPE 1."

Novel crystalline salts of 3-[l-(4-chlorophenyl)-trans-3-fluorocyclobutyl]-4,5-dicyclopropyl-r-4H-l,2,4-triazole are potent inhibitors of 11 ß-hydroxysteroid dehydrogenase Type 1 and are useful for the treatment of conditions associated with Metabolic Syndrome as well as cognitive impairment. The in...

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Bibliographische Detailangaben
Hauptverfasser: ZHAO, MATTHEW, HUFFMAN, MARK, A, LYNCH, JOSEPH, E, BEREZNITSKI, YURI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Novel crystalline salts of 3-[l-(4-chlorophenyl)-trans-3-fluorocyclobutyl]-4,5-dicyclopropyl-r-4H-l,2,4-triazole are potent inhibitors of 11 ß-hydroxysteroid dehydrogenase Type 1 and are useful for the treatment of conditions associated with Metabolic Syndrome as well as cognitive impairment. The invention also relates to pharmaceutical compositions containing these novel salts, processes to prepare these salts and their pharmaceutical compositions as well as uses thereof for the treatment of Type 2 diabetes, hyperglycemia, obesity, dyslipidemia, hypertension, and cognitive impairment.