AN IMPROVED PROCESS FOR PREPARATION OF VILDAGLIPTIN

AN IMPROVED PROCESS FOR PREPARATION OF VILDAGLIPTIN

AN IMPROVED PROCESS FOR PREPARATION OF VILDAGLIPTIN ABSTRACT The present invention relates to a process for the preparation of pure vildagliptin of Formula and a pharmaceutical composition comprising pure vildagliptin. The process comprises reacting L-prolinamide with haloacetyl chloride in one or m...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JADHAV SHANKAR DADA, DWIVEDI SHRI PRAKASH DHAR, SINGH KUMAR KAMLESH, THAKER TIRTH HARKRISHNA, TANDON NITIN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:AN IMPROVED PROCESS FOR PREPARATION OF VILDAGLIPTIN ABSTRACT The present invention relates to a process for the preparation of pure vildagliptin of Formula and a pharmaceutical composition comprising pure vildagliptin. The process comprises reacting L-prolinamide with haloacetyl chloride in one or more of organic solvents and in the presence of base, condensing the compound so obtained with 1-amino-adamantane-3-ol in the presence of a base; dehydrating the compound so obtained with dehydrating agent to obtain vildagliptin of Formula I; and optionally, purifying the vildagliptin to obtain pure vildagliptin of Formula.