PROCESS FOR PREPARATION OF STABLE PHARMACEUTICAL INTERMEDIATES OF MOISTURE SENSITIVE ACTIVE PHARMACEUTICAL INGREDIENTS

Abstract The present invention relates to a process for preparation of intermediates comprising one or more moisture-sensitive active pharmaceutical ingredients (APIs). By preparing unique intermediates as disclosed in the present invention by compaction of one or more moisture-sensitive APIs with o...

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Bibliographische Detailangaben
Hauptverfasser:	SAURABH GUPTA, AMAR AGARWAL, NAIDU, VENKATARAMANA, GIRISH KUMAR JAIN, PATTIPATI,SRIKANTH
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Abstract The present invention relates to a process for preparation of intermediates comprising one or more moisture-sensitive active pharmaceutical ingredients (APIs). By preparing unique intermediates as disclosed in the present invention by compaction of one or more moisture-sensitive APIs with one or more hydrophobic substances, it is possible to effectively control the impurity level of moisture-sensitive APIs. The pharmaceutical compositions described in the present invention may comprise one or more moisture sensitive APIs or combination of a moisture sensitive API with a non-moisture-sensitive API. The composition may provide immediate release or desired extended release of API when administered to a patient in need thereof.