CRYSTALLINE PI3 KINASE INHIBITORS

CRYSTALLINE PI3 KINASE INHIBITORS

There is provided inter alia 6 (2 ((4 arnino 3 (3 hydroxyphenyl) 1 H pyrazolo[3 4 d]pyrirnidin 1 yl) methyl) 3 (2 chlorobenzyl) 4 oxo 3 4 dihydroquinazolin 5 yl) N N bis(2 methoxyethyl)hex 5 ynamide in the form of a solid crystalline hydrate and in solid crystalline anhydrous form. There are also pr...

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Bibliographische Detailangaben
Hauptverfasser: COPMANS ALEX HERMAN, LEYS CARINA, FILLIERS WALTER FERDINAND MARIA, NIESTE PATRICK HUBERT J, VANHOUTTE FILIP MARCEL C, BROECKX RUDY LAURENT MARIA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:There is provided inter alia 6 (2 ((4 arnino 3 (3 hydroxyphenyl) 1 H pyrazolo[3 4 d]pyrirnidin 1 yl) methyl) 3 (2 chlorobenzyl) 4 oxo 3 4 dihydroquinazolin 5 yl) N N bis(2 methoxyethyl)hex 5 ynamide in the form of a solid crystalline hydrate and in solid crystalline anhydrous form. There are also provided dry powder pharmaceutical compositions for inhalation containing such solid crystalline forms.