A process for preparing 4,6-dihydrobxypyrimidine

A process for preparing 4,6-dihydrobxypyrimidine

A process for preparing 4,6-dihydroxypyrimidine comprising the steps: a) contacting formamide, an alkoxide of formula ROM and a malonate of formula CH2(CO2R)2 in a solvent of formula ROH; b) adding water to the product of step (a); c) removing substantially all of the solvent of formula ROH from the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JONES RAYMOND VINCENT HEAVON, RITCHIE DAVID JOHN, CROMBIE BARRY STUART
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A process for preparing 4,6-dihydroxypyrimidine comprising the steps: a) contacting formamide, an alkoxide of formula ROM and a malonate of formula CH2(CO2R)2 in a solvent of formula ROH; b) adding water to the product of step (a); c) removing substantially all of the solvent of formula ROH from the product of step (b); and d) acidifying the product of step (c) wherein R is C1-4 alkyl and M is an alkali metal.