A PROCESS FOR THE PRODUCTION OF 2-AMINO-3-CARBETHOXYAMINO-6-(P-FLUORO-BENZYLAMINO)-PYRIDINE-MALEATE AND MEDICINAL COMPOSITION INCLUDING SAME

A PROCESS FOR THE PRODUCTION OF 2-AMINO-3-CARBETHOXYAMINO-6-(P-FLUORO-BENZYLAMINO)-PYRIDINE-MALEATE AND MEDICINAL COMPOSITION INCLUDING SAME

There is prepared 2-amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)-pyridine-maleate of the formula The compound has antiphlogistic and analgesic properties in the same manner as the known hydrochloride salt. In contrast to the hydrochloride 2-amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)-pyridi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BEBENBURG WALTER VON, PAULUHN SIEGFRIED
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:There is prepared 2-amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)-pyridine-maleate of the formula The compound has antiphlogistic and analgesic properties in the same manner as the known hydrochloride salt. In contrast to the hydrochloride 2-amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)-pyridine-maleate can be produced without a disturbing blue coloration. This maleate generally is formed from a mixture of two crystal modifications A and B, whereby there is especial advantageous in regard to isolation as well as the galenical preparations a mixture entriched in modification A (60 to 90% modification A).