"AN IMPROVED PROCESS FOR TRIMETHOBENZAMIDE"

"AN IMPROVED PROCESS FOR TRIMETHOBENZAMIDE"

A process for preparation of trimethobenzamide hydrochloride comprising, coupling of 3,4,5-timethoxy benzoic acid with N,N-carbonyldiimidazole (CDI) in presence of inorganic base in an organic solvent and treatment of N-(3,4,5-trimethoxybenzoyl)imidazole with 4-(dimethylamino ethoxy)-benzylamine in...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: NEELAKANDAN KALIAPERUMAL, PANCHABHAI PRASAD PANDURANG, SRINIVAS NANDALA, BALASUBRAMANIAN PRABHAKARAN, MEHTA SAMIT SATISH, AHIRRAO PRAVIN PRABHAKAR, GURJAR MUKUND KESHAV
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A process for preparation of trimethobenzamide hydrochloride comprising, coupling of 3,4,5-timethoxy benzoic acid with N,N-carbonyldiimidazole (CDI) in presence of inorganic base in an organic solvent and treatment of N-(3,4,5-trimethoxybenzoyl)imidazole with 4-(dimethylamino ethoxy)-benzylamine in a base and treatment of reaction mixture with paraformaldehyde and formic acid resulting in a pure trimethobenzamide hydrochloride free from associated impurities below the regulatory limits.