METHOD OF PREPARING OF N-GLYCOSYL DERIVATIVES OF POLYENE MACROLIDE AND THE SALTS THEREOF

METHOD OF PREPARING OF N-GLYCOSYL DERIVATIVES OF POLYENE MACROLIDE AND THE SALTS THEREOF

The amino group-containing polyene macrolide is reacted with a mono- or oligosaccharide of the aldose or ketose series in an organic solvent or an organic solvent mixture. In order to be able to use an inexpensive, non-flammable solvent, the N-glycosyl derivative produced is precipitated from the re...

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Bibliographische Detailangaben
Hauptverfasser: ROSLIK-KAMINSKA D, PAWLAK J, ZIELINSKI J, BYLEC E, KOWSZYK-GINDIFER Z, PLOCIENNIK Z, KOLODZIEJCZYK P, WAGNER W, DAHLIG H, JAKOBS E, GOLIK J, BOROWSKI E, FALKOWSKI L
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Beschreibung
Zusammenfassung:The amino group-containing polyene macrolide is reacted with a mono- or oligosaccharide of the aldose or ketose series in an organic solvent or an organic solvent mixture. In order to be able to use an inexpensive, non-flammable solvent, the N-glycosyl derivative produced is precipitated from the reaction medium by means of water or an aqueous solution of an inorganic salt, purified by crystallisation from a higher alcohol, and optionally converted into a salt.