10BETA-ALKYNYLESTRENE DERIVATIVES,THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

6-Substituted 10 beta -alkynylestrene derivatives of formula (I): wherein X is hydrogen, C1-C4 alkyl or halogen; n is zero, 1 or 2; Y is an oxo group or a methylene group; the symbol @ indicates a single bond or a double bond; R1 is halogen, azido or a group wherein each of R3 and R4 is, independent...

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Bibliographische Detailangaben
Hauptverfasser:	VITTORIA VILLA, PAOLO LOMBARDI, FRANCO FAUSTINI, ENRICOSALLE
Format:	Patent
Sprache:	eng
Schlagworte:	ADDING MATERIALS TO FUELS OR FIRES TO REDUCE SMOKE ORUNDESIRABLE DEPOSITS OR TO FACILITATE SOOT REMOVAL CHEMISTRY FIRELIGHTERS FUELS FUELS NOT OTHERWISE PROVIDED FOR HUMAN NECESSITIES HYGIENE LIQUEFIED PETROLEUM GAS LUBRICANTS MEDICAL OR VETERINARY SCIENCE METALLURGY NATURAL GAS ORGANIC CHEMISTRY PEAT PETROLEUM, GAS OR COKE INDUSTRIES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS SYNTHETIC NATURAL GAS OBTAINED BY PROCESSES NOT COVERED BYSUBCLASSES C10G, C10K TECHNICAL GASES CONTAINING CARBON MONOXIDE
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Beschreibung
Zusammenfassung:	6-Substituted 10 beta -alkynylestrene derivatives of formula (I): wherein X is hydrogen, C1-C4 alkyl or halogen; n is zero, 1 or 2; Y is an oxo group or a methylene group; the symbol @ indicates a single bond or a double bond; R1 is halogen, azido or a group wherein each of R3 and R4 is, independently, hydrogen or C1-C4 alkyl, or R1 may be divalent and is a C1-C6 alkylidene group; and R2 is hydrogen or, when R1 is halogen, R2 may also be the same halogen as R1, and the pharmaceutically acceptable salts thereof; are aromatase inhibitors and can be used, e.g., in the treatment of hormone-dependent tumors and prostatic hyperplasia.