5'-modified carbocyclic ribonucleotide derivatives and methods of use

The present disclosure provides phosphate mimic derivatives of Formula (I) or (II):pharmaceutically acceptable salts thereof, and related Nucleic Acid Agents and conjugates. The present disclosure also relates to uses of the phosphate mimic derivatives (e.g., in the Nucleic Acid Agents and conjugate...

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Bibliographische Detailangaben
Hauptverfasser:	WANG Weimin, CAI Xiaochuan
Format:	Patent
Sprache:	eng ; heb
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure provides phosphate mimic derivatives of Formula (I) or (II):pharmaceutically acceptable salts thereof, and related Nucleic Acid Agents and conjugates. The present disclosure also relates to uses of the phosphate mimic derivatives (e.g., in the Nucleic Acid Agents and conjugates) in treating or preventing diseases.