An improved process for the preparation of ruxolitinib

The main objective of the present invention is to improve the process for the preparation of ruxolitinib using protected (E)-N-(3-(Dimethylamino)-2-(7H- pyrrolo[2,3-d] pyrimidin-4-yl) allylidene)-N-methylmethanaminium chloride hydrochloride and (R)-5-cyclopentylpyrazolidin-3-one D-tartrate with high...

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Bibliographische Detailangaben
Hauptverfasser:	UPPARAPALLI Sampath Kumar, RAMPALLI Sriram, BANDI Chennakesava Reddy, KOKKILIGADDA Veda Vyas, BAVIREDDI Basaveswara Rao, KALAPALA Venkateswara Rao, AREVELI Srinivas
Format:	Patent
Sprache:	eng ; heb
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The main objective of the present invention is to improve the process for the preparation of ruxolitinib using protected (E)-N-(3-(Dimethylamino)-2-(7H- pyrrolo[2,3-d] pyrimidin-4-yl) allylidene)-N-methylmethanaminium chloride hydrochloride and (R)-5-cyclopentylpyrazolidin-3-one D-tartrate with higher yields on commercial scale. Formula (I):