Trinucleotide cap analogs and methods of use thereof

Described herein are novel trinucleotide cap analogs and methods of making and using the same. Also described herein is an RNA molecule comprising a 5'-cap, wherein the 5'-cap includes a trinucleotide cap analog as described herein. Methods of inducing a therapeutic effect in a 5 subject a...

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Bibliographische Detailangaben
Hauptverfasser:	XU Chunping, KOUKHAREVA Inna, LEBEDEV Alexandre, HENDERSON Jordana Michelle, HOUSTON Michael, ILICHEV Ilya Vladimirovich, ZHAO Chanfeng, UJITA Andrew
Format:	Patent
Sprache:	eng ; heb
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Described herein are novel trinucleotide cap analogs and methods of making and using the same. Also described herein is an RNA molecule comprising a 5'-cap, wherein the 5'-cap includes a trinucleotide cap analog as described herein. Methods of inducing a therapeutic effect in a 5 subject are also described herein, the methods including a step of administering to the subject an RNA molecule including the trinucleotide cap analog.