Antifolate linker-drugs and antibody-drug conjugates

The present invention relates to novel antifolate linker-drugs, conjugates comprising such antifolate linker-drugs, and the use thereof in the treatment of diseases, such as cancer, autoimmune and infectious diseases, optionally in combination with other therapeutic agents.

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Bibliographische Detailangaben
Hauptverfasser:	ELGERSMA Ronald Christiaan, HUIJBREGTS Tijl, JOOSTEN Johannes Albertus Frederikus, BEUCKENS-SCHORTINGHUIS Christina Adriana, WAALBOER Dennis Christian Johannes
Format:	Patent
Sprache:	eng ; heb
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to novel antifolate linker-drugs, conjugates comprising such antifolate linker-drugs, and the use thereof in the treatment of diseases, such as cancer, autoimmune and infectious diseases, optionally in combination with other therapeutic agents.