Complement factor i-related compositions and methods

Provided herein are Complement Factor I (CFI) variants and CFI containing fusion constructs that exhibit at least one improved characteristic relative to a wild type CFI. The CFI variants and fusion constructs of the disclosure can exhibit tunable specificity and activity. The CFI variants and fusio...

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Bibliographische Detailangaben
Hauptverfasser:	BLOUSE Grant E, JENDROSZEK Agnieszka, OLDENBURG Emil, SCHAR Christine Ren?, IYER Shyam Rajan, MCGUIRE James N, JENSEN Jan Kristian, PELOT Kyle A
Format:	Patent
Sprache:	eng ; heb
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein are Complement Factor I (CFI) variants and CFI containing fusion constructs that exhibit at least one improved characteristic relative to a wild type CFI. The CFI variants and fusion constructs of the disclosure can exhibit tunable specificity and activity. The CFI variants and fusion constructs provided herein may be useful for treating a disease or condition associated with dysregulation of the complement system or a deficiency of CFI.