Anti-pilra antibodies, uses thereof, and related methods and reagents

Anti-pilra antibodies, uses thereof, and related methods and reagents

Provided herein are anti-PILRA antibodies with the highly desirable selectivity: having comparable binding to cynomolgus and human PILRA proteins, but much weaker binding to human PILRB protein, as well as binding to both PILRA G78 and R78 variants. The binding and selectivity profiles of the antibo...

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Bibliographische Detailangaben
Hauptverfasser: DENALI THERAPEUTICS INC, WEERAKKODY Tanya N, KIM Do Jin, MONROE Kathryn M, SABELSTR?M Hanna, TH?OLIS JR. Richard, LISAINGO Kathleen, PARK Joshua I
Format: Patent
Sprache:eng ; heb
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:Provided herein are anti-PILRA antibodies with the highly desirable selectivity: having comparable binding to cynomolgus and human PILRA proteins, but much weaker binding to human PILRB protein, as well as binding to both PILRA G78 and R78 variants. The binding and selectivity profiles of the antibodies described herein allow for them to be used in animal studies (e.g., monkeys) without the need to rely on a surrogate molecule and also when treating subjects with either PILRA variant. Further described herein, for the first time, are biological discoveries related to PILRA and the effects of reducing PILRA signaling in cells.