Agonistic ltbr antibodies and bispecific antibodies comprising them

Agonistic ltbr antibodies and bispecific antibodies comprising them

The invention relates to novel antibodies that bind to lymphotoxin beta receptor (LTBR) and to bispecific antigen binding molecules comprising these novel LTBR antibodies and an antigen binding domain that binds a tumor associated antigen, in particular to Fibroblast Activation Protein (FAP), to met...

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Bibliographische Detailangaben
Hauptverfasser: DENGL Stefan, LEISIBACH Desir?e, HOSSE Ralf, KUNZ Leo Frederik, NIKOLOV Miroslav, BORMANN Felix, GEORGES Guy, DUERR Harald, BIANCHI Roberta, MENDE Fanny, HOFFMANN-LA ROCHE INC, HEIDRICH Monika, HANISCH Lydia Jasmin, UMA?A Pablo, BRYDON Michelle Victoria, MUNDIGL Olaf, LECLAIR Stephane
Format: Patent
Sprache:eng ; heb
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to novel antibodies that bind to lymphotoxin beta receptor (LTBR) and to bispecific antigen binding molecules comprising these novel LTBR antibodies and an antigen binding domain that binds a tumor associated antigen, in particular to Fibroblast Activation Protein (FAP), to methods of producing these molecules and to methods of using the same.