Intracellular delivery compositions

Intracellular delivery compositions

Protein conjugates comprising a protein carrier comprising a plurality of amine groups, a biological payload that interacts with an intracellular target and a linker linking them, wherein at least a portion of the amine groups are bound to a protecting group are provided. Pharmaceutical compositions...

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Bibliographische Detailangaben
Hauptverfasser: BEN-MOSHE Tehila, FREILICH Shay, SHULMAN Avidor, SAPIR Yair, UZAN GUETA Rozi Ravit, SHILOVITZKY Orit, GOTTFRIED Yossi, MANDEL Ilana, FAYGENBOIM-ORNAI Rotem, EYLON Bat-Hen, CHEN ZELTSBURG Lilach, HAKIM Motti, LEWKOWICZ Ayala
Format: Patent
Sprache:eng ; heb
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Protein conjugates comprising a protein carrier comprising a plurality of amine groups, a biological payload that interacts with an intracellular target and a linker linking them, wherein at least a portion of the amine groups are bound to a protecting group are provided. Pharmaceutical compositions comprising the protein conjugates as well as methods of using and producing the protein conjugates are also provided.