Multispecific binding agents against cd40 and cd137 in combination therapy for cancer

The present invention relates to combination therapy using a binding agent that binds to human CD40 and to human CD137 in combination with a checkpoint inhibitor to reduce or prevent progression of a tumor or treating cancer.

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Bibliographische Detailangaben
Hauptverfasser:	BREIJ Esther Cornelia Wilhelmina, GUELEN Lars, BAJAJ Gaurav, NEIJSSEN Jost, KUZMANOV Ivan, MUIK Alexander, HIBBERT Richard, FELLERMEIER-KOPF Sina, PAULMANN Claudia, LABRIJN Aran Frank, SAHIN Ugur, FU Yali, NIEWOOD Michelle, GIESEKE Friederike, BECKMANN Karsten, DE KREUK Bart-Jan, SCHUURMAN Janine, HIGGS Brandon, ADAMS Homer III, FERESHTEH Mark, SPIRES Vanessa, GARRIDO CASTRO Patricia, BLUM Jordan
Format:	Patent
Sprache:	eng ; heb
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to combination therapy using a binding agent that binds to human CD40 and to human CD137 in combination with a checkpoint inhibitor to reduce or prevent progression of a tumor or treating cancer.