Substituted phenyl-1h-pyrrolo[2, 3-c]pyridine derivatives

Substituted phenyl-1h-pyrrolo[2, 3-c]pyridine derivatives

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to...

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Hauptverfasser: CAI Wei, QUEROLLE Olivier Alexis Georges, ZHANG Zhigao, LI Ming, EDWARDS James Patrick, JOUFFROY Matthieu Dominique, DENG Xiangjun, DAI Xuedong, DYUBANKOVA Natalia Nikolaevna, HULPIA Fabian, LIANG Chao, SCHEPENS Wim Bert Griet, DEMIN Samu?l Dominique, THURING Johannes Wilhelmus J, DARVILLE Nicolas Freddy Jacques Bruno, NG Alicia Tee Fuay, SUN Zhen, PANDE Vineet, LEPRI Susan
Format: Patent
Sprache:eng ; heb
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Zusammenfassung:The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.