Co-expression of constructs and immunostimulatory compounds

The present invention relates to vectors, such as DNA plasmids, comprising multiple nucleic acid sequences engineered to be co-expressed as separate molecules. Such separate molecules include a first polypeptide, wherein the first polypeptide comprises a targeting unit that targets antigen-presentin...

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Bibliographische Detailangaben
Hauptverfasser: BERSAAS Audun Trygge Haugen, GRANUM Stine, DILLARD Pierre, FREDRIKSEN Agnete Brunsvik
Format: Patent
Sprache:eng ; heb
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Beschreibung
Zusammenfassung:The present invention relates to vectors, such as DNA plasmids, comprising multiple nucleic acid sequences engineered to be co-expressed as separate molecules. Such separate molecules include a first polypeptide, wherein the first polypeptide comprises a targeting unit that targets antigen-presenting cells, a multimerization unit, such as dimerization unit, and an antigenic unit comprising one or more antigens or parts thereof, and one or more immunostimulatory compounds.