Exatecan derivatives and antibody-drug conjugates thereof

Exatecan derivatives and antibody-drug conjugates thereof

Disclosed herein, in part, are compounds (I) which are exatecan derivatives with novel chemical linkers that include cathepsin B cleavable moieties, and conjugated to targeting antibodies.

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Bibliographische Detailangaben
Hauptverfasser: STROP Peter, VRLJIC Marija, WONG Janica Cheuk-ying, PONS Jaume
Format: Patent
Sprache:eng ; heb
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed herein, in part, are compounds (I) which are exatecan derivatives with novel chemical linkers that include cathepsin B cleavable moieties, and conjugated to targeting antibodies.