Pyridine derivatives with c-linked cyclic substituents as cgas inhibitors

Pyridine derivatives with c-linked cyclic substituents as cgas inhibitors

The invention relates to new proline derivatives of formula (I) as cGAS inhibitors,whereinR1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and G are defined as in claim 1,and prodrugs or pharmaceutically acceptable salts of these compoundsfor the treatment of diseases such as systemic lupus erythematosus, sy...

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Bibliographische Detailangaben
Hauptverfasser: HEIMANN Annekatrin Charlotte, HANDSCHUH Sandra Ruth, GNAMM Christian, GROSS Patrick, GODBOUT C?drickx, GRUNDL Marc Alexander, KUTTRUFF Christian Andreas, REINERT Dirk, HOENKE Christoph, KLEY Joerg, STUBER Raphael, THEIS Theodor
Format: Patent
Sprache:eng ; heb
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The invention relates to new proline derivatives of formula (I) as cGAS inhibitors,whereinR1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and G are defined as in claim 1,and prodrugs or pharmaceutically acceptable salts of these compoundsfor the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), non-alcoholic steatotic hepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).