Method of optimizing a filling recipe for a drug container

Method of optimizing a filling recipe for a drug container

A method of filing a vial. The method includes providing a pump corresponding to a vial and setting a drip retraction parameter for the pump to any value equal to or less than 20 degrees. The method also includes setting a no adjustment limit for a fill weight of the vial to T1, with T1 being at or...

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Bibliographische Detailangaben
Hauptverfasser: QI Wei, GOSWAMI Devrishi, PADMAKUMAR Vikashni, LE David, ZHANG Jun, PIEDMONTE Deirdre, SANTOS Maria Raquel
Format: Patent
Sprache:eng ; heb
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Zusammenfassung:A method of filing a vial. The method includes providing a pump corresponding to a vial and setting a drip retraction parameter for the pump to any value equal to or less than 20 degrees. The method also includes setting a no adjustment limit for a fill weight of the vial to T1, with T1 being at or in a range of about 2% more or less than a fill weight of a target fill weight T0, wherein a process performance index Cpk (Cpk) for the vial throughout a fil cycle exceeds a minimum value.