Antibodies and antigen binding peptides for factor xia inhibitors and uses thereof

The present invention provides novel antigen binding peptides, such as an antibody or antibody fragment, that specifically bind to selective FXIa inhibitors and/or dual inhibitors of FXIa, and plasma kallikrein. The present invention further relates to methods of reducing the antithrombotic effect o...

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Bibliographische Detailangaben
Hauptverfasser:	LUETTGEN Joseph M, AN Yongmi, SCHNEEWEIS Lumelle, PINCKNEY Jason Robert, YAMNIUK Aaron Paul, RAKESTRAW Ginger Chao, SHERIFF Steven, KRYSTEK JR. Stanley Richard, KISH Kevin, EWING William R, DILGER Andrew Karl, TERRAGNI Christina
Format:	Patent
Sprache:	eng ; heb
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
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Beschreibung
Zusammenfassung:	The present invention provides novel antigen binding peptides, such as an antibody or antibody fragment, that specifically bind to selective FXIa inhibitors and/or dual inhibitors of FXIa, and plasma kallikrein. The present invention further relates to methods of reducing the antithrombotic effect of FXIa inhibitors by administering to a subject a pharmaceutically effective dose of the antigen binding peptides provided herein. In addition, the present invention provides detection reagents and methods for detecting the level of the inhibitors of FXIa in a biological sample.