Bicyclic 1,4-diazepanones and therapeutic uses thereof

Provided herein are compounds of formula (I):or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein.Also provided herein is a pharmaceutically acceptable composition comprising a compound...

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Bibliographische Detailangaben
Hauptverfasser:	Takuya MAKINO, Kazuyuki TSUCHIYA, Wenyue WANG, Toshio KUROSAKI, Ryuichi SEKIOKA, Scott COLLIBEE, Naoto KATOH, Bradley P. MORGAN, Chris EVANS, Eriko HONJO, Pu-Ping LU, Ikumi KURIWAKI, Susumu YAMAKI, Makoto YAMASAKI, Yuka KOIZUMI
Format:	Patent
Sprache:	eng ; heb
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein are compounds of formula (I):or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein.Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing.Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.