Photosynthetically controlled spirulina extracts for treating the cytokine storm syndrome

Spirulina extracts and/or fractionated compounds thereof, sublingual spray formulation thereof, spraying devices for using the formulation, as well as methods of preparing and using the spirulina extracts to treat TNF-α related inflammation are provided. The spirulina extracts are prepared by water extraction of Arthrospira spp. biomass that is cultivated under controlled, ultra-high-density conditions with strong UV illumination and strong continuous mixing, and are characterized by high levels of c-phycocyanin, sorbitol and adenosine derivates-which were found to have a strong low-dose effect of reducing TNF-α secretion. The spirulina extracts may correspondingly be used to prevent or alleviate cytokine storm related to various infections or autoimmune diseases.