Formulation, dosage regimen, and manufacturing process for heterodimeric fc-fused proteins

The present invention relates to pharmaceutical formulations for heterodimeric Fc-fused proteins which are advantageous for achieving higher titers of the proteins during production, higher stability during storage, and improved efficacy when used as a therapeutic. Also provided are dosage regimens...

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Bibliographische Detailangaben
Hauptverfasser:	BRAUN Alexandra, GUTIERREZ Eva, KIRBY Patrick, NAILL Michael C, MORGAN Christopher Ryan, O'NEIL Steven, CUILLEROT Jean-Marie, GRINBERG Asya, DEROSE Mark, BIGELOW Mitchell, WAGTMANN Nicolai, SHIFRIN Michael, CHEUNG Ann F
Format:	Patent
Sprache:	eng ; heb
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to pharmaceutical formulations for heterodimeric Fc-fused proteins which are advantageous for achieving higher titers of the proteins during production, higher stability during storage, and improved efficacy when used as a therapeutic. Also provided are dosage regimens for such heterodimeric Fc-fused proteins and pharmaceutical formulations for use in treating cancer, such as locally advanced or metastatic solid tumor.