Systems and methods for image quality enhancement for multi-head camera

A nuclear medicine (NM) multi-head imaging system is provided that includes a gantry, detector units, and at least one processor. The gantry defines a bore. The detector units are mounted to the gantry and configured to rotate as a group with the gantry around the bore in rotational steps, with each detector unit configured to sweep about a corresponding axis and acquire imaging information while sweeping about the corresponding axis. The at least one processor is coupled to the detector units and configured to determine a region of interest (ROI) of the object to be imaged; determine a sweeping configuration based on the size of the ROI; determine a rotational movement configuration for the gantry using the determined sweeping configuration; and control the gantry and the set of detector units to utilize the determined rotational movement and sweeping configurations during acquisition of imaging information.