Pharmaceutical formulations and dosage regimens for multi-specific binding proteins that bind her2, nkg2d, and cd16 for cancer treatment

Pharmaceutical formulations and dosage regimens for multi-specific binding proteins that bind her2, nkg2d, and cd16 for cancer treatment

This disclosure relates to pharmaceutical formulations for multi-specific binding proteins having an epidermal growth factor receptor 2 (ErbB2 or HER2)-binding scFv, an NKG2D-binding Fab, and an antibody Fc domain. Also provided are dosage regimens for such multi-specific binding proteins and pharma...

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Hauptverfasser: GRINBERG Asya, ONEIL Steven, NAILL Michael C, WEI Ronnie, HANEY William, MORGAN Christopher Ryan, FALLON Daniel, WAGTMANN Nicolai, CUILLEROT Jean-Marie, CHANG Gregory P, CHEUNG Ann F
Format: Patent
Sprache:eng ; heb
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Zusammenfassung:This disclosure relates to pharmaceutical formulations for multi-specific binding proteins having an epidermal growth factor receptor 2 (ErbB2 or HER2)-binding scFv, an NKG2D-binding Fab, and an antibody Fc domain. Also provided are dosage regimens for such multi-specific binding proteins and pharmaceutical formulations for use in treating cancer, such as locally advanced or metastatic solid tumor.