A dry powder inhaler and system for drug delivery

An inhalation system for delivering a dry powder medicament to a pulmonary tract, comprises a dry powder inhaler configured to have at least two inlet apertures, wherein a first inlet aperture is in communication with a first air flow pathway and a second inlet aperture is in communication with a se...

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Bibliographische Detailangaben
Hauptverfasser: ANTHONY BRYANT, P. SPENCER KINSEY, JOHN M. POLIDORO, CARL R. SAHI, CHAD C. SMUTNEY, BENOIT ADAMO, TOM HE, SCOTT MCLEAN, ALFRED MANN, DENNIS OVERFIELD
Format: Patent
Sprache:eng ; heb
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Beschreibung
Zusammenfassung:An inhalation system for delivering a dry powder medicament to a pulmonary tract, comprises a dry powder inhaler configured to have at least two inlet apertures, wherein a first inlet aperture is in communication with a first air flow pathway and a second inlet aperture is in communication with a second air flow pathway. The first airflow pathway and the second airflow pathway converge in a substantially perpendicular manner during an inhalation maneuver for deagglomerating powder particles. The inhalation system has a total resistance to flow in a dosing configuration ranging in value from 0.065 to about 0.200 (ˆškPa)/liter per minute. The inhaler may contain a cohesive powder e.g. a diketopiperazine, and the powder may contain insulin or another medicament.