Quinoline or quinazoline compound and application thereof

The present invention relates to quinoline or quinazoline compound represented by the formula (I), a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a prodrug molecule thereof, or a deuterated compound thereof. The compound of the present invention is effective in inhibiting the ac...

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Bibliographische Detailangaben
Hauptverfasser: CHAN Shingpan, PENG Xia, AI Jing, TAN Li, DAI Yang, DING Ke, REN Xiaomei, LU Xiaoyun, GENG Meiyu, TU Zhengchao, ZHANG Zhang, DING Jian
Format: Patent
Sprache:eng ; heb
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Zusammenfassung:The present invention relates to quinoline or quinazoline compound represented by the formula (I), a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a prodrug molecule thereof, or a deuterated compound thereof. The compound of the present invention is effective in inhibiting the action of AXL protein kinase and can inhibit proliferation, migration, and invasion of various tumor cells. Further, the quinoline or quinazoline compound of the present invention has excellent metabolic stability, high in vivo antitumor activity, low toxic side effects, and can be used for preparing a drug for preventing hyperproliferative diseases such as tumors in humans and other mammals.