Kv7 channel activators compositions and methods of use

Provided herein are optionally substituted benzoimidazol-1,2-yl amides, pharmaceutical compositions comprising a therapeutically effective amount of such compounds and a pharmaceutically acceptable excipient, and methods of treating Kv7 associated diseases, such as, epilepsy, amyotrophic lateral scl...

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Bibliographische Detailangaben
Hauptverfasser: LYNN RESNICK, MICHAEL E. BOZIK, JAMES S. HALE, CHARLES A. FLENTGE, DAVID A. MARESKA, GEORGE T. TOPALOV, JUSTIN K. BELARDI, SCOTT S. HARRIED
Format: Patent
Sprache:eng ; heb
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Zusammenfassung:Provided herein are optionally substituted benzoimidazol-1,2-yl amides, pharmaceutical compositions comprising a therapeutically effective amount of such compounds and a pharmaceutically acceptable excipient, and methods of treating Kv7 associated diseases, such as, epilepsy, amyotrophic lateral sclerosis, various types of pain, hyperexcitability, a dyskinesia, dystonia, mania and tinnitus with such compounds and pharmaceutical compositions.