Chimeric antigen receptors targeting cd70

Chimeric antigen receptors targeting cd70

The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic m...

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Bibliographische Detailangaben
Hauptverfasser: Mathilde Brunnhilde DUSSEAUX, Siler PANOWSKI, Tao SAI, Roman Ariel GALETTO, Barbra Johnson SASU, Niranjana Aditi NAGARAJAN, Yoon PARK, Surabhi SRIVATSA SRINIVASAN, Thomas John VAN BLARCOM
Format: Patent
Sprache:eng ; heb
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Beschreibung
Zusammenfassung:The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic methods for use of these CARs and engineered immune cells comprising these CARs for the treatment of a condition associated with malignant cells expressing CD70 (e.g., cancer).