Bispecific antibody construct directed to muc17 and cd3

Bispecific antibody construct directed to muc17 and cd3

The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3E chain and optionally a third domain, which is a specific Fc modality. Moreover, the inventio...

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Bibliographische Detailangaben
Hauptverfasser: PENDZIALEK Jochen, CHEN Irwin, BAILIS Julie, WAHI Joachim, RAUM Tobias, ROSS Sandra, ARVEDSON Tara, DAHLHOFF Christoph, NAHRWOLD Elisabeth, BLUMEL Claudia
Format: Patent
Sprache:eng ; heb
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Beschreibung
Zusammenfassung:The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3E chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.