Process for the preparation of n-((1r,2s,5r)-5-(tert-butylamino)-2-((s)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide

Process for the preparation of n-((1r,2s,5r)-5-(tert-butylamino)-2-((s)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide

The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide,as well as novel intermediates employed in the process, which may be useful for the...

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Hauptverfasser: DOMAGALSKI Nathan R, FOREST Robert V, FAN Yu, BOROVIKA Alina, AYTAR Burcu Selin, LAUSER Kathleen, GREEN Rebecca A, FENSTER Michael David Bengt, LEAHY David K, SAVAGE Scott A, ZHU Ye, LA CRUZ Thomas E, LEE Hong Geun, RAZLER Thomas M, HICKEY Matthew R, ZHENG Bin, ZARETSKY Serge, DEERBERG Joerg, CHAN Collin, EASTGATE Martin D, LUO Helen Y, SOUMEILLANT Maxime C.D, GONZALEZ-BOBES Francisco, SFOUGGATAKIS Chris, KOPP Nathaniel David
Format: Patent
Sprache:eng ; heb
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Zusammenfassung:The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide,as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.