In vitro neonatal biomimetic (nmimic) model and methods of using same

In vitro neonatal biomimetic (nmimic) model and methods of using same

In vitro biomimetic models of the neonatal immune system are provided along with methods of using the models in pre-clinical assessment of infant immune cell-mediated and humoral responses to immunogenic stimulation, such as vaccination. The models include one comprising cord blood-derived T follicu...

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Bibliographische Detailangaben
Hauptverfasser: TIRUMALAI KAMALA, VAUGHAN WITTMAN, DONALD DRAKE, JANICE MOSER, LUIS MOSQUERA, WILLIAM WARREN, EVAN GOMES
Format: Patent
Sprache:eng ; heb
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Zusammenfassung:In vitro biomimetic models of the neonatal immune system are provided along with methods of using the models in pre-clinical assessment of infant immune cell-mediated and humoral responses to immunogenic stimulation, such as vaccination. The models include one comprising cord blood-derived T follicular helper cells and B cells, and one comprising cord blood-derived dendritic cells and CD4+ T cells. The models can be used, for example, to assess candidate vaccines via analysis of cellular responses to antigen and vaccine exposure.