Dimethoxyphenyl substituted indole compounds as tlr7, tlr8 or tlr9 inhibitors

Dimethoxyphenyl substituted indole compounds as tlr7, tlr8 or tlr9 inhibitors

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These comp...

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Bibliographische Detailangaben
Hauptverfasser: HAQUE Tasir S, MUSSARI Christopher P, MACOR John E, DYCKMAN Alaric J, LOMBARDO Louis J, PASUNOORI Laxman, DODD Dharmpal S, KUMAR Sreekantha Ratna, POSS Michael A
Format: Patent
Sprache:eng ; heb
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Zusammenfassung:Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.