Antibodies specific for hyperphosphorylated tau and methods of use thereof

The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment...

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Bibliographische Detailangaben
Hauptverfasser:	MARIGO Mauro, ROSENQVIST Nina Helen, HELBO Lone, PEDERSEN Jan Torleif, TAGMOSE Lena, DAVID Laurent, JUHL Karsten, DAECHSEL Justus Claus Alfred, ASUNI Abdur-Rasheed, CHRISTENSEN Soren, JENSEN Thomas, VOLBRACHT Christiane, PEDERSEN Lars Ostergaard, KJAERGAARD Kristian
Format:	Patent
Sprache:	eng ; heb
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.