Reagent nozzle sipper mixing system and method

An analysis instrument may perform analytical operations on an analyte that is combined with multiple reagents prior to being introduced into a flow cell. The instrument may include a nozzle sipper that aspirates reagents from a recipient, along with an analyte. The reagents may be directed to a vol...

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Bibliographische Detailangaben
Hauptverfasser: BRYAN Debra Sue, WHITACRE Johanna Lynn, WANG Michael Dai, CLARK Stephen Wayne, ALVAREZ Michelle L, NIZIOLEK Michael Adalbert, OSMUS James Michael, DREWS Bradley Kent, ULMANELLA Umberto, PHELPS Steven Scott, DARLAND Joshua Augustin
Format: Patent
Sprache:eng ; heb
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Zusammenfassung:An analysis instrument may perform analytical operations on an analyte that is combined with multiple reagents prior to being introduced into a flow cell. The instrument may include a nozzle sipper that aspirates reagents from a recipient, along with an analyte. The reagents may be directed to a volume and may be repeatedly moved into and out of the volume by cycling of a pump. The reagents may be ejected into a destination recipient with the nozzle sipper promoting vorticity in the recipient to enhance mixing. The repeated aspiration and ejection through the nozzle sipper effectively mixes the reagents and the template in an automated or semi-automated fashion.