Method of computational protein design

A method for constructing a library of amino-acid sequences having a common structural fold, and a method for designing and selecting an amino-acid sequence having a desired affinity to a molecular surface of interest of a molecular entity, using the library, are provided herein. The methods are bas...

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Hauptverfasser: Sarel FLEISHMAN, Christoffer NORN, Maria Gabriele PSZOLLA, Gideon LAPIDOTH
Format: Patent
Sprache:eng ; heb
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Zusammenfassung:A method for constructing a library of amino-acid sequences having a common structural fold, and a method for designing and selecting an amino-acid sequence having a desired affinity to a molecular surface of interest of a molecular entity, using the library, are provided herein. The methods are based on a stochastic sampling of backbone conformations and amino acid conservation patterns observed in experimentally available protein structures having the common structural fold.