PROCESS FOR PREPARING ISOLATED ALPHA-CRYSTAL FORM OF METHANESULFONIC ACID ADDITION SALTS OF IMATINIB

PROCESS FOR PREPARING ISOLATED ALPHA-CRYSTAL FORM OF METHANESULFONIC ACID ADDITION SALTS OF IMATINIB

This invention relates to the methanesulfonic acid addition salts of Imatinib and to the synthesis thereof. In particular, this invention relates to the synthesis of crystalline α-form of Imatinib methanesulfonate. Furthermore, the invention is directed to a novel acid addition salt of 4-(4-methylpi...

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Bibliographische Detailangaben
Hauptverfasser: MAGDALENA GLICE, KATARYZNA KORCZAK, URSZULA FRACZEK, BOGDAN ZAGRODZKI, WIESLAW SZELEJEWSKI, WOJCIECH SZCZEPEK, DOROTA SAMSON-LAZINSKA, PIOTR CMOCH, WIOLETA MARUSZAK, MARTA LAWECKA, RYSZARD MODZELEWSKI, LUKASZ KACZMAREK
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:This invention relates to the methanesulfonic acid addition salts of Imatinib and to the synthesis thereof. In particular, this invention relates to the synthesis of crystalline α-form of Imatinib methanesulfonate. Furthermore, the invention is directed to a novel acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-[(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]benzamide with two molecules of methanesulfonic acid and to the polymorphic forms thereof, as well as to their pharmaceutical compositions.