PROCESS FOR ISOLATING OF CYCLOSPORIN-A

PROCESS FOR ISOLATING OF CYCLOSPORIN-A

A process is disclosed for the solution chromatographic purification of cyclosporin A from a starting mixture containing one or more of cyclosporin A, B, C, other cyclosporin components that are more polar or more apolar than cyclosporin A, and other like contaminants, by heating the starting mixtur...

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Hauptverfasser: SZANYA,TIBOR, MELCZER,ISTVAN, MAKO,GYOERGYNE, KARACSONY,ERNOE, MARTON,GYULA, DEAK,GYOERGY, STRBKA,ANDRASNE, NAGYNE ARVAI,EDIT, HAJDUFI,CSABA, KARCZUB,ANITA, DENCS,BELANE, RADNAI,FERENC, KELEMEN,JANOS, HANAK,LASZLO, BALINT,JANOS, KERI,VILMOS
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:A process is disclosed for the solution chromatographic purification of cyclosporin A from a starting mixture containing one or more of cyclosporin A, B, C, other cyclosporin components that are more polar or more apolar than cyclosporin A, and other like contaminants, by heating the starting mixture or an evaporation residue thereof to a temperature from about 80 DEG C. to about 115 DEG C., melting the heated starting mixture, and carrying out solution chromatography of the melted material, suitably first in a 48:50:2 mixture of chloroform, dichloromethane, and ethanol, and then in a mixture of like proportions, of the solvents chloroform, ethylacetate, and ethanol.