PROCESS FOR PREPARATION CYCLIC NITRONES AND PHARMECEUTICAL COMPOSITIONS COMPRISING THEM

A cycllc nltrone of the formula: in which R1 and R2 are each independently represented by a C 1-3 alkyl or R1 and R2 together form a C2-7 alkylene chain; n is represented by an integer from 0-2; and R is represented by a substituent selected from the group consisting of hydrogen, halogen C1-4 alkyl,...

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Hauptverfasser: CARR,ALBERT ANTHONY, THOMAS,CRAIG EUGENE, KU,GEORGE, BERNOTAS,RONALD CHARLES
Format: Patent
Sprache:eng
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Zusammenfassung:A cycllc nltrone of the formula: in which R1 and R2 are each independently represented by a C 1-3 alkyl or R1 and R2 together form a C2-7 alkylene chain; n is represented by an integer from 0-2; and R is represented by a substituent selected from the group consisting of hydrogen, halogen C1-4 alkyl, C1-4 alkoxy, -CF3, -0CF3 and -OH and their use as spin trapping agents and interleukin-1 inhibitor.