PROCESS FOR THE PREPARATION OF 2-ALKYL-THIO-4-HYDRAZINO-5-FLUOROPYRIMIDINES

PROCESS FOR THE PREPARATION OF 2-ALKYL-THIO-4-HYDRAZINO-5-FLUOROPYRIMIDINES

2-Alkylthio-4-hydrazino-5-fluoropyrimidines can be prepared from 2,4-dichloro-5-fluoropyrimidine in good yield with high selectivity by treatment with 2 equivalents of alkyl mercaptan in the presence of base followed by treatment with hydrazine.

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Bibliographische Detailangaben
Hauptverfasser: JOHNSON,TIMOTHY C, NASUTAVICUS,WILMONTE A, GULBENKIAN,AYLIN H
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:2-Alkylthio-4-hydrazino-5-fluoropyrimidines can be prepared from 2,4-dichloro-5-fluoropyrimidine in good yield with high selectivity by treatment with 2 equivalents of alkyl mercaptan in the presence of base followed by treatment with hydrazine.