MICROBIOLOGICAL METHOD FOR PRODUCTION OF HYDROXIL-GROUP SUBSTITUTED AROMATIC HETEROCYCLIC CARBONIC ACID

A novel microbiological process for the preparation of hydroxylated heterocyclic carboxylic acids of the formula starts from the corresponding heterocyclic carboxylic acid. This process is carried out in such a way that a) aerobic biomass which utilises nicotinic acid is cultivated in a molar ratio...

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Hauptverfasser:	KIENER,ANDREAS, HEINZMANN,KLAUS, ROHNER,MARKUS
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A novel microbiological process for the preparation of hydroxylated heterocyclic carboxylic acids of the formula starts from the corresponding heterocyclic carboxylic acid. This process is carried out in such a way that a) aerobic biomass which utilises nicotinic acid is cultivated in a molar ratio of nicotinic acid to mineral acid of 1 to 8, this ratio being ensured throughout the culture period, and then b) the hydroxylation of the corresponding heterocyclic carboxylic acid of the general formula. in which R1 and X have the said meaning, is carried out with this biomass. Under these conditions it is possible in the culture period to accumulate microorganisms of the species Pseudomonas acidovorans DSM 7205, of the species Pseudomonas acidovorans DSM 7203, of the species Alcaligenes faecalis DSM 7204 and microorganisms with the identifier DSM 7202.